Jane Grande-Allen headshot

WEBSITE(S)| https://profiles.rice.edu/faculty/k-jane-grande-allen

Mentored presenters may have participated in these courses

BIOE 401

Student Project Titles List

Mechanically Induced Endothelial Cell Inflammation

Elucidating the Role of Androgens in Calcific Aortic Valve Disease Progression in Porcine Aortic Valvular Interstitial Cells

Using Hydrogel Coatings to Alter Heart Valve Surfaces

Research Areas

Jane Grande-Allen’s research applies engineering analysis to understand and fight heart valve disease. This involves mechanical testing, biochemical measurements, and microstructural analysis of critical components found in the extracellular matrix (ECM) that makes up cardiac tissue. Her studies into the basic and applied physiology of heart valve tissue have shown that the ECM – collagen, elastin, glycosaminoglycans and proteoglycans – forms an intricate network of connective tissue that is influenced by valvular function, growth, and abnormalities.